Extended Resection of Cavernous Sinus Medial Wall Improves Remission Rates in Somatotroph Pituitary Neuroendocrine Tumors: A Strategy to Inspect Anatomical Interface
In somatotroph PitNETs, intraoperative identification of occult invasion combined with extended resection of MWCS significantly improved biochemical remission rates, particularly in Knosp grade 3-4 subgroups. And this selective approach maintained a surgically validated safety profile without increasing overall surgical morbidity. However, MWCS resection should be judiciously avoided in lesions with intact pseudocapsular integrity or circumscribed by a normal pituitary gland.
Authors
- Mei Luo (ORCID: https://orcid.org/0000-0002-1950-4204)
- Bihua Luo (ORCID: https://orcid.org/0000-0001-9385-175X)
- Zhifeng Sheng (ORCID: https://orcid.org/0000-0003-2308-3024)
- Xinpeng Du (ORCID: https://orcid.org/0000-0002-4816-7227)
- Zhan Tong (ORCID: https://orcid.org/0000-0002-0261-1388)
- Min Liu (ORCID: https://orcid.org/0000-0002-5059-3743)
- Jian Gu (ORCID: https://orcid.org/0009-0004-2418-0170)
- Yong Peng (ORCID: https://orcid.org/0000-0002-8778-0358)
- Ling Tian
Institutions
- Central South University (CN)
- National Clinical Research (US)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- World Neurosurgery
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1016/j.wneu.2025.123883
- Citations
- 1
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.29