Enhancer binding as a KEysTONE of fasting response
Fasting is a recurrent daily energy stress that benefits healthspan and lifespan. While ketones fuel fasting in vertebrates, the underlying transcriptional mechanism remains incompletely understood. Recently, Korenfeld et al. revealed peroxisome proliferator-activated receptor alpha (PPARα)-dependent enhancer priming as a keystone for ketone production, increasing our understanding of mechanisms underlying metabolic benefits of alternate-day fasting (ADF).
Authors
- Nathaniel F. Henneman
- Ganna Panasyuk (ORCID: https://orcid.org/0000-0002-5591-848X)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Institut Necker Enfants Malades (FR)
- Délégation Paris 6 (FR)
Publication Details
- Journal
- Trends in Endocrinology and Metabolism
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1016/j.tem.2025.02.002
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Research Council
- H2020 European Research Council