Epigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac pathology and early indicators of cardiac risk
Using the largest series of left ventricular tissue to date, this study investigates the causal role of cardiac methylation changes in DCM and suggests targets for experimental studies to probe DCM pathogenesis.
Authors
- Kenneth B. Margulies (ORCID: https://orcid.org/0000-0002-8093-4465)
- Thomas P. Cappola (ORCID: https://orcid.org/0000-0002-9630-7204)
- Marie Chiew Shia Loh (ORCID: https://orcid.org/0000-0003-3626-8466)
- Pritesh Jain (ORCID: https://orcid.org/0000-0002-3720-8409)
- Darwin Tay (ORCID: https://orcid.org/0000-0002-4309-2772)
- Chang Jie Mick Lee (ORCID: https://orcid.org/0000-0001-6673-9391)
- Eleanor Wong
- Michael P. Morley (ORCID: https://orcid.org/0000-0002-0958-7376)
- Gurpreet K. Singhera (ORCID: https://orcid.org/0000-0002-8422-0857)
- Konstanze Tan (ORCID: https://orcid.org/0000-0003-2663-3327)
- Wilson Lek Wen Tan (ORCID: https://orcid.org/0000-0002-5054-8512)
- Roger Foo (ORCID: https://orcid.org/0000-0002-8079-4618)
- Paul Hanson (ORCID: https://orcid.org/0000-0002-0655-4843)
- Fei Li Tai
- Hong Kiat Ng
Institutions
- Agency for Science, Technology and Research (SG)
- National University of Singapore (SG)
- Nanyang Technological University (SG)
- National University Health System (SG)
- Genome Institute of Singapore (SG)
- University of Pennsylvania (US)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1186/s13148-025-01854-8
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81