Treatment of Haemophilus influenzae Serotype A (Hia) Meningitis in a Pediatric Patient: A Case Report

<i>Haemophilus influenzae</i> serotype A (Hia) meningitis is a rare but severe pediatric infection, with significant risks of mortality and long-term complications. Here, we describe a 10-week-old male presenting with Hia meningitis complicated by cerebritis, seizures, and central venous catheter-related deep vein thrombosis (CADVT). The patient initially presented with fever, irritability, and feeding difficulties and was later found to have significant laboratory abnormalities and cerebrospinal fluid (CSF) findings suggestive of bacterial meningitis. This case highlights the empiric treatment of pediatric meningitis, tailored and adjunctive treatments based on culture results, and other thrombotic and neurological complications. Despite high morbidity risks, the patient demonstrated complete clinical recovery at two years and showed no signs of long-term sequelae. This case emphasizes the evolving epidemiology of Hia and the importance of timely diagnosis and multidisciplinary management in severe pediatric infections, to ensure the minimization of negative externalities.

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Publication Details

Journal
Cureus
Published
2025-03-08
DOI
https://doi.org/10.7759/cureus.80253
Primary Topic
Bacterial Infections and Vaccines
Type
article
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0.00
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article

Treatment of Haemophilus influenzae Serotype A (Hia) Meningitis in a Pediatric Patient: A Case Report

Shriji Patel, Miriam Thomas, Matthew C. Thomas, Harthik Kambhampati
Cureus
Bacterial Infections and Vaccines
article

Treatment of Haemophilus influenzae Serotype A (Hia) Meningitis in a Pediatric Patient: A Case Report

Shriji Patel, Miriam Thomas, Matthew C. Thomas, Harthik Kambhampati
article en

Abstract

<i>Haemophilus influenzae</i> serotype A (Hia) meningitis is a rare but severe pediatric infection, with significant risks of mortality and long-term complications. Here, we describe a 10-week-old male presenting with Hia meningitis complicated by cerebritis, seizures, and central venous catheter-related deep vein thrombosis (CADVT). The patient initially presented with fever, irritability, and feeding difficulties and was later found to have significant laboratory abnormalities and cerebrospinal fluid (CSF) findings suggestive of bacterial meningitis. This case highlights the empiric treatment of pediatric meningitis, tailored and adjunctive treatments based on culture results, and other thrombotic and neurological complications. Despite high morbidity risks, the patient demonstrated complete clinical recovery at two years and showed no signs of long-term sequelae. This case emphasizes the evolving epidemiology of Hia and the importance of timely diagnosis and multidisciplinary management in severe pediatric infections, to ensure the minimization of negative externalities.

CureusVol. 17(3)
Lake Erie College of Osteopathic Medicine (US), Digital Heritage Netherlands (NL)
Good health and well-being
Openalex Percentile: Top 95%
Bacterial Infections and Vaccines
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Treatment of Haemophilus influenzae Serotype A (Hia) Meningitis in a Pediatric Patient: A Case Report — Shriji Patel, Miriam Thomas, et al. · Cureus (2025) | TGRS Research Map | TGRS