Design and evaluation of emulgel with a polyherbal basis for topical delivery

Topical drug delivery systems involve applying formulations directly to the skin to treat various skin diseases, providing a localized therapeutic effect while minimizing systemic side effects. However, conventional gel formulations often face challenges in delivering hydrophobic drugs effectively due to their limited solubilizing capacity and poor drug permeability. To address these limitations, a novel approach called emulgel combines the advantages of gels and emulsions, enhancing the delivery of hydrophobic drugs through the skin. This study focuses on the development and evaluation of an herbal emulgel formulated using extracts of Curcuma longa, Tinospora cardifolia, and Salacia chinensis, known for their antimicrobial and therapeutic properties. The prepared various batches for the formulation underwent rigorous assessment for various parameters, including physical appearance, pH, homogeneity, spreadability, viscosity, centrifugation stability, and in vitro drug release analysis. Additionally, it was characterized for swelling index, drug content uniformity, and globule size, ensuring a comprehensive evaluation. The emulgel exhibited pH levels compatible with skin application, excellent spreadability, uniform homogeneity, and optimal viscosity, ensuring better patient compliance and stability. The in vitro drug release studies demonstrated a controlled and sustained release profile, further enhancing its therapeutic potential. Overall, the formulation met satisfactory standards across all parameters, showcasing its efficacy as a promising antimicrobial agent, with the potential to improve topical drug delivery and patient outcomes significantly.