Rutin attenuates bleomycin-induced acute lung injury via miR-9-5p mediated NF-κB signaling inhibition: network pharmacology analysis and experimental evidence
Combining network pharmacology and an in vivo study revealed that miR-9-5p/Nfkb1 axis could mediate the meliorative effect of rutin against BLM-induced ALI.
Authors
- Ahmed F. Soliman (ORCID: https://orcid.org/0000-0002-8401-1553)
- Fatema Suliman Alatawi (ORCID: https://orcid.org/0000-0002-3595-7828)
- Eman Rashad (ORCID: https://orcid.org/0000-0002-2489-6628)
- Awatif M. E. Omran (ORCID: https://orcid.org/0000-0001-7803-3273)
- Omnia N. Abdel-Rahman
Institutions
- Ain Shams University (EG)
- Cairo University (EG)
- University of Tabuk (SA)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-05
- DOI
- https://doi.org/10.3389/fphar.2025.1522690
- Citations
- 2
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 1.61