IL-1β stimulates ADAMTS9 expression and contributes to preterm prelabor rupture of membranes
Maternal serum ADAMTS9 levels at mid-gestation are promising non-invasive biomarkers for pPROM risk stratification. Mechanistically, IL-1β-induced NF-κB activation promotes ADAMTS9 expression and POFUT2-dependent secretion, contributing to fetal membrane weakening. These findings provide new insights into the role and potential therapeutic target for sterile intra-amniotic inflammation in pPROM.
Authors
- Chunliu Liu
- Jiasong Cao (ORCID: https://orcid.org/0000-0003-3517-9592)
- Yongmei Shen
- Ling Shuai (ORCID: https://orcid.org/0000-0003-0671-7478)
- Qimei Lin
- Shihan Yao
- Lei Zhang (ORCID: https://orcid.org/0000-0003-4284-2604)
- Yixin Wang (ORCID: https://orcid.org/0000-0002-8062-0765)
- Xu Chen (ORCID: https://orcid.org/0000-0003-4303-8116)
- Ling Chen (ORCID: https://orcid.org/0000-0002-9448-4100)
- Shuqi Wang (ORCID: https://orcid.org/0000-0002-1384-4830)
- Zongjin Li (ORCID: https://orcid.org/0000-0002-4603-3743)
- Wen Li (ORCID: https://orcid.org/0000-0002-1747-9594)
- Ying Chang (ORCID: https://orcid.org/0009-0008-9146-8122)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Tianjin University (CN)
- Nankai University (CN)
- Tianjin Central Hospital of Gynecology Obstetrics (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1186/s12964-025-02120-3
- Citations
- 2
- Primary Topic
- Preterm Birth and Chorioamnionitis
- Type
- article
- Field-Weighted Citation Impact
- 2.71