Hepatitis B Core-Related Antigen Point-of-Care Tests as a Risk Stratification Tool for Treatment Eligibility: Experience From Kenya
We undertook a point-of-care test for hepatitis B core-related antigen in adults with hepatitis B virus in Kilifi, Kenya. A positive test identified all individuals with a hepatitis B viral load >200 000 IU/mL and who were hepatitis B e antigen positive. It also correlated with a higher alanine aminotransferase (ALT) level (<i>P</i> = .03), raised aspartate transaminase-to-platelet ratio index (APRI) (<i>P</i> < .001), and higher elastography scores (<i>P</i> = .03).
Authors
- Yasuhito Tanaka (ORCID: https://orcid.org/0000-0002-2473-6966)
- Louise Downs (ORCID: https://orcid.org/0000-0002-6088-4704)
- Monique Andersson (ORCID: https://orcid.org/0000-0003-0619-1074)
- Yusuke Shimakawa (ORCID: https://orcid.org/0000-0002-4198-4785)
- Nadia Aliyan (ORCID: https://orcid.org/0000-0001-7046-4108)
- George Githinji (ORCID: https://orcid.org/0000-0001-9640-7371)
- Oscar Chirro (ORCID: https://orcid.org/0000-0002-1799-8503)
- Philippa Clare Matthews (ORCID: https://orcid.org/0000-0002-4036-4269)
- Anthony Etyang (ORCID: https://orcid.org/0000-0003-1267-6422)
- Dorcas Okanda (ORCID: https://orcid.org/0000-0003-3039-5544)
- Mwanakombo Zaharani
- Benson Safari
Institutions
- University College Hospital (GB)
- Institut Pasteur (FR)
- Université Paris Cité (FR)
- Pwani University (KE)
- The Francis Crick Institute (GB)
- Kenya Medical Research Institute (KE)
- University of Oxford (GB)
- National Center for Global Health and Medicine (JP)
- Moving the GoalPosts (KE)
- Oxford University Hospitals NHS Trust (GB)
- Institute of Infection and Immunity (CA)
- University College London (GB)
- Wellcome Trust (GB)
- Kumamoto University (JP)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1093/ofid/ofaf125
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Francis Crick Institute