Mechanosensitive Ion Channel PIEZO1 as a Key Regulator of Intestinal Fibrosis in Crohn’s Disease
PIEZO1 plays a pivotal role in the regulation of intestinal fibrosis by maintaining the levels of HIF-1α, thereby promoting EMT. Therapeutic strategies targeting PIEZO1 could be used to prevent intestinal fibrosis in CD patients.
Authors
- Chang Su (ORCID: https://orcid.org/0000-0003-4937-3249)
- Xiaodong Yang (ORCID: https://orcid.org/0000-0002-4971-2362)
- Manli Zhang (ORCID: https://orcid.org/0000-0002-7704-4525)
- Li Zuo (ORCID: https://orcid.org/0000-0002-7340-5995)
- Qiao Mei (ORCID: https://orcid.org/0000-0002-0635-6564)
- Qiuyuan Liu
- Luyao Zhang (ORCID: https://orcid.org/0000-0001-9408-9496)
- Juan Wu (ORCID: https://orcid.org/0000-0001-6973-4641)
- Hao Ding (ORCID: https://orcid.org/0000-0001-8456-8311)
- Jing Hu (ORCID: https://orcid.org/0000-0001-9290-2850)
- Wei Han
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1093/ibd/izaf041
- Citations
- 6
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 6.99
Funders
- National Natural Science Foundation of China