Regioselective Synthesis of β,γ-Unsaturated Amides from Unactivated Alkenes
β,γ-Unsaturated amides are valuable substrates for downstream functionalization reactions but can be challenging to prepare. Herein, we introduce an approach featuring the regioselective addition of carbamoyl chlorides to unactivated alkenes, present its scope and limitations, and exemplify its synthetic utility.
Authors
- Daniel Kaiser (ORCID: https://orcid.org/0000-0001-8895-9969)
- Bogdan R. Brutiu (ORCID: https://orcid.org/0000-0003-3952-8120)
- Nuno Maulide (ORCID: https://orcid.org/0000-0003-3643-0718)
- Sabela Vega-Ces
Institutions
- University of Vienna (AT)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1021/acs.joc.5c00093
- Citations
- 2
- Primary Topic
- Advanced Synthetic Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Österreichischen Akademie der Wissenschaften
- Austrian Science Fund
- H2020 European Research Council