Transcriptomics, lipidomics, and single-nucleus RNA sequencing integration: exploring sphingolipids in MASH-HCC progression
Our findings provided valuable insights into the role of sphingolipids in the progression of MASH to HCC. Specific serum and liver sphingolipid profiles may serve as valuable biomarkers for diagnosis and prognosis in MASH-HCC.
Authors
- Qianhua Yan
- Grayson W. Way (ORCID: https://orcid.org/0000-0002-5765-2064)
- Xixian Jiang (ORCID: https://orcid.org/0000-0001-5280-8894)
- Huiping Zhou (ORCID: https://orcid.org/0000-0002-0050-372X)
- Nan Wu (ORCID: https://orcid.org/0000-0001-5594-5042)
- Arun Jayant Sanyal (ORCID: https://orcid.org/0000-0001-8682-5748)
- Sayed Obaidullah Aseem (ORCID: https://orcid.org/0000-0003-3234-1769)
- Jing Zeng (ORCID: https://orcid.org/0000-0001-7764-155X)
- Xuan Wang (ORCID: https://orcid.org/0000-0002-3528-5785)
- Jian‐Gao Fan (ORCID: https://orcid.org/0000-0002-8618-6402)
- Lianyong Su
- Yunling Tai
- P B Hylemon
- Emily C. Gurley
- Derrick Zhao
Institutions
- Shanghai Jiao Tong University (CN)
- Virginia Commonwealth University (US)
- XinHua Hospital (CN)
- Virginia Commonwealth University Medical Center (US)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1186/s13578-025-01362-5
- Citations
- 5
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.77
Funders
- U.S. Department of Veterans Affairs
- Division of Diabetes, Endocrinology, and Metabolic Diseases