PRMT5 highly expressed on CD16 + CD56- natural killer cells is correlated with NK cells exhaustion in colorectal cancer mesenchyme
The microenvironment of CRC is in an immunosuppressive state characterized mainly by high expression of TIGIT, CD16, PRMT5, and SIGIRR; low expression of CD56, IFN-γ, and CD69; significantly decreased percentage of CD56 + NK cells; and significantly increased percentage of CD16 + CD56- NK cells with weakened killing ability. PRMT5 and TIGIT may be closely related to the formation of CD16 + CD56- NK cells with weakened killing ability.
Authors
- Z. D. Nie (ORCID: https://orcid.org/0000-0002-0234-4208)
- Juan-Juan Chang
- Yuangang Liu (ORCID: https://orcid.org/0000-0002-4179-6629)
- Chao Wang (ORCID: https://orcid.org/0000-0002-7460-7628)
- Hai Ning Shi (ORCID: https://orcid.org/0000-0002-5526-3233)
- Z. Q. Yang (ORCID: https://orcid.org/0009-0004-9526-8567)
- Qian Tu
- Qingguo Yan
- Kaixuan Zeng
- Ying Guo (ORCID: https://orcid.org/0000-0002-3959-4569)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Northwest University (CN)
- Yan'an University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1007/s00262-025-03981-w
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China