Gastrointestinal Dysfunction and Low‐Grade Inflammation Associate With Enteric Neuronal Amyloid‐β in a Model for Amyloid Pathology
Our findings indicate that amyloid-β accumulation in enteric neurons is associated with low-grade intestinal inflammation and altered motility and suggest that peripheral pathology may cause gastrointestinal dysfunction in Alzheimer's disease patients.
Authors
- Marion J. Gijbels (ORCID: https://orcid.org/0000-0002-4906-0384)
- Werend Boesmans (ORCID: https://orcid.org/0000-0002-2426-0451)
- Kinga Réka Tasnády (ORCID: https://orcid.org/0000-0002-8406-9106)
- Bert Brône (ORCID: https://orcid.org/0000-0002-4851-9480)
- Ilse Dewachter
- Manuel Gutiérrez de Ravé (ORCID: https://orcid.org/0000-0001-8545-1166)
- Veerle Melotte (ORCID: https://orcid.org/0000-0002-9459-123X)
- Reindert Jehoul (ORCID: https://orcid.org/0000-0002-6929-4129)
Institutions
- Maastricht University Medical Centre (NL)
- Erasmus MC (NL)
- Amsterdam University Medical Centers (NL)
- Hasselt University (BE)
Publication Details
- Journal
- Neurogastroenterology & Motility
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1111/nmo.15016
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Fonds Wetenschappelijk Onderzoek
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Universiteit Hasselt
- Vlaamse regering
- Fondation Francqui - Stichting