<scp>DRD2‐</scp> Mediated <scp>AMPK</scp> Ubiquitination Regulates the Occurrence of Hepatic Steatosis
In conclusion, this study demonstrated that internalisation of DRD2 in a high-fat environment aggravated MASH progression through the AKT-AMPK signalling axis. Furthermore, L-741626, as a DRD2 antagonist, has the potential to treat MASH.
Authors
- Yuanli Zhang (ORCID: https://orcid.org/0000-0003-0682-0037)
- Yu Ou (ORCID: https://orcid.org/0000-0002-1794-7861)
- Jianan Cai (ORCID: https://orcid.org/0009-0008-7618-2951)
- Peng Ma (ORCID: https://orcid.org/0000-0001-7125-8891)
- Hao Ou
Institutions
- China Pharmaceutical University (CN)
Publication Details
- Journal
- Liver International
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1111/liv.70053
- Citations
- 2
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Priority Academic Program Development of Jiangsu Higher Education Institutions