Parkinsonism in Alzheimer's disease without Lewy bodies in association with nigral neuron loss: A data‐driven clinicopathologic study
One in 10 Alzheimer's disease (AD) patients without Lewy bodies had parkinsonism. Parkinsonism in AD was correlated with reduced nigral neuron density. TAR DNA-binding protein 43 pathology was associated with nigral degeneration in AD. AD should be included in the differential diagnosis of dementia with parkinsonism.
Authors
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Shunsuke Koga (ORCID: https://orcid.org/0000-0001-8868-9700)
- Daisuke Ono (ORCID: https://orcid.org/0000-0002-0238-7355)
- Melissa E. Murray (ORCID: https://orcid.org/0000-0001-7379-2545)
- Hiroaki Sekiya (ORCID: https://orcid.org/0000-0001-9683-5966)
- Andreas Maier (ORCID: https://orcid.org/0000-0002-9550-5284)
Institutions
- Hospital of the University of Pennsylvania (US)
- Jacksonville College (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/alz.14628
- Citations
- 9
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 12.50