Blood Metabolome Mediates the Effect of the Plasma Lipidome on the Risk of Atrial Fibrillation: A Mendelian Randomization Study
Our study identified a causal relationship between plasma liposomes and AF, and additionally found that the plasma metabolite homoarginine levels can act as a mediator of the lipid sterol ester in its effect on AF.
Authors
- Zhiyuan Jiang
- Yi Ning (ORCID: https://orcid.org/0000-0002-7737-580X)
- Guoqiang Zhong (ORCID: https://orcid.org/0009-0003-2550-6980)
- Yu‐Wen Su (ORCID: https://orcid.org/0000-0001-6730-8219)
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Clinical Cardiology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/clc.70112
- Citations
- 1
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China