Coenzyme Q10 alleviates AlCl3 and D-galactose induced Alzheimer via modulating oxidative burden and TLR-4/MAPK pathways and regulation microRNA in rat brain
Coenzyme Q10 (CoQ10) improved the rats' passive avoidance memory impairment caused by D-gal and AlCl<sub>3</sub>. ad led to the alteration of the TLR-4/MAPK pathways.CoQ10 as a protective agent, diminishes oxidative burden, improve ion homeostasis.CoQ10 counteracts Alzheimer's disease by enhancing neurotransmitter parameter and regulating the MicroRNA.CoQ10 lowered accumulation of Aβ plaque in the hippocampal neurons of D-Gal and AlCl<sub>3</sub>-treated rats.One promising therapeutic method was the combination of donepezil and CoQ10 therapy.
Authors
- Nagat Fawzy Nawar (ORCID: https://orcid.org/0009-0002-2656-8668)
- Ehab Tousson (ORCID: https://orcid.org/0000-0001-9722-3603)
- Mai M. El-Keey
- Tarek M. Mohamed (ORCID: https://orcid.org/0000-0002-4015-7542)
- Doha M. Beltagy
Institutions
- Damanhour University (EG)
- Tanta University (EG)
Publication Details
- Journal
- Toxicology Research
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1093/toxres/tfaf031
- Citations
- 2
- Primary Topic
- Coenzyme Q10 studies and effects
- Type
- article
- Field-Weighted Citation Impact
- 1.61