Mesenchymal stem cell-derived small extracellular vesicles reduced hepatic lipid accumulation in MASLD by suppressing mitochondrial fission
The insights from this study provide a new perspective on the mechanism of MSC-sEV in reducing lipid accumulation and offer a potential therapeutic target by targeting DRP1 to inhibit hepatocyte steatosis and the progression of MASLD.
Authors
- L.-P. Liu
- Yongmin Yan (ORCID: https://orcid.org/0000-0002-1990-1170)
- Fuji Yang
- Yujie Shi
- Yifei Chen (ORCID: https://orcid.org/0000-0001-6644-4403)
- Yanjin Wang (ORCID: https://orcid.org/0009-0005-1484-2537)
- Wei Luo (ORCID: https://orcid.org/0000-0003-1818-3469)
- Jing Zhou
Institutions
- Jiangsu University (CN)
- Xuzhou Medical College (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1186/s13287-025-04228-2
- Citations
- 7
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 9.48
Funders
- National Natural Science Foundation of China