A deep‐learning retinal aging biomarker for cognitive decline and incident dementia
RetiPhenoAge, a retinal aging marker, was studied in an Asian memory clinic cohort. Older RetiPhenoAge predicted future cognitive decline and incident dementia. It also linked to neuropathological markers, and plasma proteomic profiles of aging. UK Biobank replication found that RetiPhenoAge predicted 12-year incident dementia. Future studies should validate RetiPhenoAge as a prognostic biomarker for dementia.
Authors
- Narayanaswamy Venketasubramanian (ORCID: https://orcid.org/0000-0003-3593-6362)
- Simon Nusinovici (ORCID: https://orcid.org/0000-0002-9599-5818)
- Ten Cheer Quek (ORCID: https://orcid.org/0000-0002-6987-3366)
- Christopher Chen (ORCID: https://orcid.org/0000-0002-1047-9225)
- Qing Peng (ORCID: https://orcid.org/0000-0002-6991-9432)
- Mark Richards (ORCID: https://orcid.org/0000-0002-2023-8177)
- Can Can Xue (ORCID: https://orcid.org/0000-0002-2747-6215)
- Ching‐Yu Cheng (ORCID: https://orcid.org/0000-0003-0655-885X)
- Eugene S.J. Tan (ORCID: https://orcid.org/0000-0001-7273-6883)
- Marco Yu (ORCID: https://orcid.org/0000-0002-2825-8914)
- Saima Hilal (ORCID: https://orcid.org/0000-0001-5434-5635)
- Ming Ann Sim (ORCID: https://orcid.org/0000-0002-5699-3553)
- Hyungwon Choi (ORCID: https://orcid.org/0000-0002-6687-3088)
- Eddie Chong (ORCID: https://orcid.org/0009-0006-5818-1635)
- Mitchell K.P. Lai (ORCID: https://orcid.org/0000-0001-7685-1424)
- Yih Chung Tham (ORCID: https://orcid.org/0000-0002-6752-797X)
- Yuan Cai (ORCID: https://orcid.org/0000-0002-7551-2866)
- Miao Li Chee (ORCID: https://orcid.org/0000-0003-1620-692X)
- Siew Pang Chan
- Boon Yeow Tan
Institutions
- National University of Singapore (SG)
- Chinese University of Hong Kong (HK)
- Singapore National Eye Center (SG)
- Raffles Institution (SG)
- National University Heart Centre Singapore (SG)
- Singapore Eye Research Institute (SG)
- Duke-NUS Medical School (SG)
- National University Hospital (SG)
- National University Health System (SG)
- St Luke's Hospital (SG)
- University of Otago (NZ)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/alz.14601
- Citations
- 11
- Primary Topic
- Retinal Imaging and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 14.96
Funders
- National University of Singapore
- National University Health System
- Medical Research Council
- National Medical Research Council