Developing and validating a prediction tool for cerebral amyloid angiopathy neuropathological severity
The severity of cerebral amyloid angiopathy (CAA) can only be determined post mortem. A web tool, the Florey CAA Score (FCAAS), was developed to predict CAA severity. The FCAAS holds the potential to be used for CAA risk stratification in clinics. CAA is linked to increased risk of amyloid-related imaging abnormalities (ARIAs). The framework used by FCAAS can possibly be adapted to predict ARIAs risk.
Authors
- Chloe A. Mutimer (ORCID: https://orcid.org/0000-0001-9143-5760)
- Nawaf Yassi (ORCID: https://orcid.org/0000-0002-0685-0060)
- Guangyan Ji (ORCID: https://orcid.org/0000-0003-4088-9636)
- Colin L. Masters (ORCID: https://orcid.org/0000-0003-3072-7940)
- Liang Jin (ORCID: https://orcid.org/0000-0003-1695-3300)
- Yijun Pan (ORCID: https://orcid.org/0000-0002-1442-3333)
- Benjamin Goudey (ORCID: https://orcid.org/0000-0002-2318-985X)
- Yihan Wang (ORCID: https://orcid.org/0000-0002-5353-6250)
- Liwei Ma (ORCID: https://orcid.org/0000-0002-7867-8060)
- Huan‐Zhong Shi (ORCID: https://orcid.org/0000-0002-1154-7920)
- Chenyin Chu
Institutions
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/alz.14583
- Citations
- 6
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 8.34
Funders
- Alzheimer's Association
- National Health and Medical Research Council