Cellular pharmacology of tenofovir alafenamide and emtricitabine in neutrophils and platelets in people with and without HIV
Our findings highlight differential drug disposition across cell types that also vary by serostatus in DBS and platelets. The mechanisms and implications of these findings require additional research.
Authors
- Martin Williams (ORCID: https://orcid.org/0009-0008-1573-8725)
- Vincent Mainella
- Ryan P Coyle (ORCID: https://orcid.org/0000-0001-6472-7020)
- Sarah R. Hosford (ORCID: https://orcid.org/0009-0009-5874-9843)
- Ye Ji Choi (ORCID: https://orcid.org/0000-0002-0167-175X)
- Travis G. Nemkov (ORCID: https://orcid.org/0000-0001-8566-7119)
- Jia‐Hua Zheng (ORCID: https://orcid.org/0000-0003-1737-524X)
- Brian R. Branchford (ORCID: https://orcid.org/0000-0002-4076-270X)
- Peter L. Anderson (ORCID: https://orcid.org/0000-0002-1200-8494)
- B. D. Johnson
- Kristina M. Brooks (ORCID: https://orcid.org/0000-0002-3832-8699)
- Lane R. Bushman
- Jennifer J. Kiser
Institutions
- Medical College of Wisconsin (US)
- Versiti Blood Center of Wisconsin (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Montana (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1093/jac/dkaf052
- Citations
- 1
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Gilead Sciences
- Colorado Clinical and Translational Sciences Institute