Postoperative Radiation With or Without Concurrent Chemotherapy for Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma With Multiple Intermediate Risks: A Propensity Score‐Matched Study

In our PSM study, LA-HNSCC patients with intermediate risk(s) did not benefit from postoperative CRT compared to RT alone. Although patients with multiple intermediate risks had significantly worse survivals, postoperative CRT did not improve OS and EFS. The results of this study may support avoiding unnecessary acute and late toxicity associated with adding chemotherapy to postoperative RT in patients with intermediate risk(s).