Monocytes from patients with myelodysplastic syndrome inhibit natural killer cell-mediated antitumor function through the CD200/CD200R pathway
Our study found that elevated CD200 expression on monocytes in patients with MDS correlates with poor prognosis, suggesting CD200 as a potential prognostic marker. Blocking CD200 enhances NK cell activation and cytotoxicity, indicating that CD200 blockade therapy could enhance antitumor responses in patients with MDS.
Authors
- Zhaoyun Liu (ORCID: https://orcid.org/0000-0002-2730-1562)
- Nianbin Li (ORCID: https://orcid.org/0000-0003-2426-509X)
- Mengyue Tian (ORCID: https://orcid.org/0000-0001-8311-8669)
- Kai Ding (ORCID: https://orcid.org/0000-0002-5412-5453)
- Hui Liu (ORCID: https://orcid.org/0000-0003-0287-7423)
- Rong Fu (ORCID: https://orcid.org/0000-0002-9928-9224)
- Xiaohan Liu (ORCID: https://orcid.org/0000-0002-1154-8122)
- Yixuan Guo (ORCID: https://orcid.org/0000-0002-7967-5873)
Institutions
- Tianjin Medical University General Hospital (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1016/j.intimp.2025.114394
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68