Id2 exacerbates the development of rheumatoid arthritis by increasing IFN‐γ production in CD4<sup>+</sup> T cells
Pro-inflammatory cytokines are significantly upregulated in the synovial fluid T cells in rheumatoid arthritis patients. The expression of pro-inflammatory cytokine interferon-γ (IFN-γ) positively correlates with the high expression of inhibitor of differentiation 2 (Id2). The inhibition or ablation of Id2 can effectively suppress IFN-γ production and the onset and progression of arthritis.
Authors
- Haoyang Sun (ORCID: https://orcid.org/0000-0003-2022-9665)
- Ping Zhu (ORCID: https://orcid.org/0000-0002-8391-4945)
- Kui Zhang (ORCID: https://orcid.org/0000-0002-8448-3278)
- Jiawei Wang (ORCID: https://orcid.org/0000-0003-3885-6296)
- Bei Zhang (ORCID: https://orcid.org/0000-0002-6355-185X)
- Zhaohui Zheng (ORCID: https://orcid.org/0000-0001-7804-4474)
- Junfeng Jia
- Peiyan Zhang (ORCID: https://orcid.org/0000-0002-7788-0515)
- Jinlin Miao
- Haomiao Shen
Institutions
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/ctm2.70242
- Citations
- 3
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- National Natural Science Foundation of China