Semantic variant primary progressive aphasia with <i>ANXA11</i> p.D40G
The pathogenic variant of annexin A11 (ANXA11I) is linked to frontotemporal dementia (FTD) syndrome. ANXA11 (p.D40G) may be one of the possible genetic causes of semantic variant primary progressive aphasia (svPPA). ANXA11 (p.D40G) may enhance heteromeric amyloid filaments of annexin A11 and TDP-43, promoting frontotemporal lobar degeneration with TAR DNA-binding protein-43 (TDP-43) inclusions (FTLD-TDP) type C.
Authors
- Young‐Eun Kim
- Na‐Yeon Jung (ORCID: https://orcid.org/0000-0002-8265-9508)
- So Young Moon (ORCID: https://orcid.org/0000-0002-1025-1968)
- Ahro Kim (ORCID: https://orcid.org/0000-0003-0836-9358)
- Kyung Won Park (ORCID: https://orcid.org/0000-0002-6788-5267)
- Hyemin Jang (ORCID: https://orcid.org/0000-0003-3152-1274)
- William W. Seeley (ORCID: https://orcid.org/0000-0003-1410-2027)
- Hee Jin Kim (ORCID: https://orcid.org/0000-0002-3186-9441)
- Eun‐Joo Kim (ORCID: https://orcid.org/0000-0002-8460-1377)
- Soo Jin Yoon
- Sun Min Lee (ORCID: https://orcid.org/0000-0001-5917-015X)
Institutions
- Ulsan College (KR)
- University of California, San Francisco (US)
- Eulji University (KR)
- Samsung Medical Center (KR)
- Seoul National University Hospital (KR)
- University of Ulsan (KR)
- University Memory and Aging Center (US)
- Pusan National University Hospital (KR)
- Ulsan University Hospital (KR)
- Pusan National University Yangsan Hospital (KR)
- Hanyang University (KR)
- Dong-A University (KR)
- Ajou University (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/alz.14566
- Citations
- 9
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- Ministry of Science and ICT, South Korea
- Korea National Institute of Health