<i>Akkermansia muciniphila</i> Modulates Central Nervous System Autoimmune Response and Cognitive Impairment by Inhibiting Hippocampal <scp>NLRP3</scp>‐Mediated Neuroinflammation
Our results suggest that A. muciniphila holds promise as a probiotic for treating NLRP3-associated inflammatory disorders and cognitive impairment, including MS.
Authors
- Yingqiong Xiong
- Xiaojun Shi (ORCID: https://orcid.org/0000-0001-5740-4098)
- Xin Hu (ORCID: https://orcid.org/0000-0001-5113-1869)
- Daojun Hong (ORCID: https://orcid.org/0000-0003-1380-3534)
- Xiaomu Wu (ORCID: https://orcid.org/0000-0002-3352-7568)
- Hao Chen (ORCID: https://orcid.org/0000-0002-0606-7914)
- Xiaobing Li (ORCID: https://orcid.org/0000-0001-5961-2114)
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-2139-3697)
- Wan‐Ying Huang (ORCID: https://orcid.org/0000-0003-0461-7182)
- Daifan Lin (ORCID: https://orcid.org/0000-0001-9957-4968)
- Yi Ouyang (ORCID: https://orcid.org/0000-0001-6318-196X)
Institutions
- Nanchang University (CN)
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1111/cns.70320
- Citations
- 5
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province