Fructose as a key biomarker for prognostication in idiopathic obstructive azoospermia associated with <i>CFTR</i> and <i>ADGRG2</i> gene variants
Approximately 47% of iOA patients carry CFTR and ADGRG2 variants, characterized by significantly lower semen volume, fructose, and pH. Fructose was identified as an independent predictor of CFTR and ADGRG2 variants, highlighting its potential utility in guiding genetic testing and clinical decision-making in iOA patients.
Authors
- Ling Zhou (ORCID: https://orcid.org/0000-0001-9493-4602)
- Jin Li (ORCID: https://orcid.org/0000-0002-5891-8135)
- Hui Chen (ORCID: https://orcid.org/0000-0002-3709-6494)
- Ping Yuan (ORCID: https://orcid.org/0000-0001-5367-8753)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-6995-1686)
- Xiaohui Ji (ORCID: https://orcid.org/0009-0007-9039-4507)
- Jing Tian
- Zhongkun Liang
- Tuerxunayi Yalikun
Institutions
- Sun Yat-sen University (CN)
- Jinan University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
Publication Details
- Journal
- Andrology
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1111/andr.70014
- Citations
- 1
- Primary Topic
- Urological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.84
Funders
- Natural Science Foundation of Guangdong Province