Therapeutic Targeting of Decr1 Ameliorates Cardiomyopathy by Suppressing Mitochondrial Fatty Acid Oxidation in Diabetic Mice
Our study delineates a molecular mechanism by which Decr1 potentiated higher mitochondrial lipid oxidation and cardiac damage by enhancing HADHA deacetylation through the PDK4/HDAC3 signalling pathway.
Authors
- Qingbo Lu (ORCID: https://orcid.org/0009-0005-6786-9100)
- Xinyu Meng (ORCID: https://orcid.org/0000-0002-3872-6232)
- Kaixin Zhou
- Jian Zhu (ORCID: https://orcid.org/0000-0002-4629-9883)
- Ashley Zhang (ORCID: https://orcid.org/0009-0000-0753-0838)
- Chenyang Zhao (ORCID: https://orcid.org/0000-0002-2100-580X)
- Yao Wang (ORCID: https://orcid.org/0000-0001-9578-9128)
- Hai‐Jian Sun (ORCID: https://orcid.org/0000-0002-7791-5335)
- Yuan Zhang
- Xiao Feng (ORCID: https://orcid.org/0000-0002-3282-5301)
- Jia‐Bao Su
- Zheng‐Yang Bao
- Haiyan Sun
- Guo Chen (ORCID: https://orcid.org/0000-0002-5200-5802)
- Hong‐Bo Qiu
- Xue‐Xue Zhu (ORCID: https://orcid.org/0009-0003-9847-6882)
- Zhanmin Lv (ORCID: https://orcid.org/0009-0009-8583-2845)
- An‐Jing Xu
Institutions
- Jiangnan University (CN)
- China Pharmaceutical University (CN)
- Yantai University (CN)
- Wuxi Fourth People's Hospital (CN)
- Jiangsu Province Hospital (CN)
- Wuxi People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1002/jcsm.13761
- Citations
- 11
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 15.27
Funders
- National Natural Science Foundation of China
- Jiangnan University
- Natural Science Foundation of Jiangsu Province
- Fundamental Research Funds for the Central Universities