Pocket guide: biologics in upper and lower airways in adults
The introduction of biologics for the treatment of severe upper and lower (type 2) airway inflammation has been a game changer in the management of these diseases. Biologics are injectable medications targeting different molecules relevant in (type 2) inflammation in patients with severe (type 2) airway diseases, like asthma, eosinophilic chronic obstructive pulmonary disease (COPD), chronic rhinosinusitis (CRS) and those who remain uncontrolled despite regular treatment. After the phase 3 trials, showing significant impact on symptoms, quality of life and interventions like surgery (for the upper airways) and exacerbations needing hospitalisation (for the lower airways), biologics are now used in daily practice in many parts of the world. This pocket guide is aimed at all specialists treating adult patients with severe airway disease.
Authors
- Manuel Bernal‐Sprekelsen (ORCID: https://orcid.org/0000-0001-8191-9833)
- Sven Schneider (ORCID: https://orcid.org/0000-0001-6438-1971)
- S.E. Lee
- Marjolein Cornet
- Santiago Quirce (ORCID: https://orcid.org/0000-0001-8086-0921)
- Peter W. Hellings (ORCID: https://orcid.org/0000-0001-6898-688X)
- Basile N. Landis (ORCID: https://orcid.org/0000-0001-6034-3724)
- Peter J. Barnes (ORCID: https://orcid.org/0000-0002-5122-4018)
- Dermot Ryan (ORCID: https://orcid.org/0000-0002-4115-7376)
- Michael E. Wechsler (ORCID: https://orcid.org/0000-0003-3505-2946)
- Guy Joos (ORCID: https://orcid.org/0000-0002-3149-9444)
- Mina Gaga (ORCID: https://orcid.org/0000-0002-9949-6012)
- Zuzana Diamant (ORCID: https://orcid.org/0000-0003-0133-0100)
- V. Backer
- Ratko Djukanović (ORCID: https://orcid.org/0000-0001-6039-5612)
- Eugenio De Corso (ORCID: https://orcid.org/0000-0001-5761-7018)
- J K Han (ORCID: https://orcid.org/0009-0001-9270-1677)
- Anju T. Peters (ORCID: https://orcid.org/0000-0003-0745-2379)
- Susanne Lau (ORCID: https://orcid.org/0000-0002-5189-4265)
- Diego M. Conti (ORCID: https://orcid.org/0000-0002-8896-495X)
- Brent A. Senior (ORCID: https://orcid.org/0000-0002-1503-3150)
- Ian Pavord (ORCID: https://orcid.org/0000-0002-4288-5973)
- Claire Hopkins (ORCID: https://orcid.org/0000-0003-3993-1569)
- G K Scadding
- Philippe Gevaert (ORCID: https://orcid.org/0000-0002-1629-8468)
- Valerie Lund
- L. Bjermer
- Joaquim Mullol
- W. J. Fokkens
Institutions
- Northwestern University (US)
- Eastern Virginia Medical School (US)
- King's College London (GB)
- Lund University (SE)
- National Jewish Health (US)
- Ghent University (BE)
- University of Oxford (GB)
- Alrijne Ziekenhuis (NL)
- Hygeia Hospital (GR)
- European Federation of Allergy and Airways Diseases Patients Associations (BE)
- Royal National Throat Nose and Ear Hospital (GB)
- Skåne University Hospital (SE)
- University College London (GB)
- Charité - Universitätsmedizin Berlin (DE)
- University of Colorado Denver (US)
Publication Details
- Journal
- Rhinology Journal
- Published
- 2025-03-01
- DOI
- https://doi.org/10.4193/rhin24.510
- Citations
- 4
- Primary Topic
- Pediatric health and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 10.07