<scp>RALYL</scp> Overexpression Suppresses Colorectal Cancer via Modulating <scp>HNRNPC</scp>‐Mediated <scp>MNK2</scp> Alternative Splicing
RALYL potentially exerts an inhibitory effect on CRC by engaging with HNRNPC to orchestrate the alternative splicing of MNK2. RALYL binds to HNRNPC to promote MNK2 splicing into MNK2a instead of MNK2b, consequently activating the p38 MAPK signaling pathway and inhibiting tumor proliferation in CRC. Our findings suggest that RALYL might suppress CRC through binding to HNRNPC to promote MNK2 splicing toward MNK2a, thereby activating the p38 MAPK signaling cascade.
Authors
- Jianbin Zhu (ORCID: https://orcid.org/0000-0002-4716-6628)
- Zenghui Ma (ORCID: https://orcid.org/0000-0003-4745-204X)
- Zhanjun Hu
- Yufei Feng (ORCID: https://orcid.org/0000-0002-4591-7432)
- Guangming Wu (ORCID: https://orcid.org/0000-0003-1923-7609)
- Mei Chen (ORCID: https://orcid.org/0000-0001-6809-147X)
- Xiaoliang Wang (ORCID: https://orcid.org/0000-0001-9851-0436)
- Xiaolong Liu (ORCID: https://orcid.org/0000-0002-3096-4981)
- Feng Liu (ORCID: https://orcid.org/0009-0005-5378-0658)
Institutions
- Fudan University (CN)
- Inner Mongolia People's Hospital (CN)
- Pudong Medical Center (CN)
- Children's Hospital of Fudan University (CN)
Publication Details
- Journal
- Cancer Reports
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/cnr2.70179
- Citations
- 1
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.81