Relationship of cognitive decline with glucocerebrosidase activity and amyloid‐beta 42 in <scp>DLB</scp> and <scp>PD</scp>
Our study provides important evidence on the relationship between brain Aβ deposition and GCase activity in the Lewy body disease spectrum independent of their genetic mutation profile. This information could be relevant for designing future clinical trials targeting these pathways.
Authors
- Jodi Maple‐Grødem (ORCID: https://orcid.org/0000-0001-7142-0078)
- Maria Camila González (ORCID: https://orcid.org/0000-0003-1061-4164)
- Linn Oftedal (ORCID: https://orcid.org/0000-0003-1793-4013)
- Cristian Falup‐Pecurariu (ORCID: https://orcid.org/0000-0002-7394-7161)
- Ewa Papuć (ORCID: https://orcid.org/0000-0002-8595-2857)
- Ole‐Bjørn Tysnes (ORCID: https://orcid.org/0000-0002-7230-6426)
- Merçé Boada (ORCID: https://orcid.org/0000-0003-2617-3009)
- Dag Aarsland (ORCID: https://orcid.org/0000-0001-6314-216X)
- Konrad Rejdak (ORCID: https://orcid.org/0000-0002-7019-6681)
- Diego Tovar (ORCID: https://orcid.org/0000-0003-3490-9899)
- Guido Alves (ORCID: https://orcid.org/0000-0003-0630-2870)
- Jakub Hort (ORCID: https://orcid.org/0000-0002-1080-3726)
- Johannes Lange (ORCID: https://orcid.org/0000-0003-0604-4891)
- Daniel Andres Alcolea (ORCID: https://orcid.org/0000-0002-3819-3245)
- Claire Paquet (ORCID: https://orcid.org/0000-0002-2273-7316)
- Marta Marquié
Institutions
- Medical University of Lublin (PL)
- Universitat Autònoma de Barcelona (ES)
- Inserm (FR)
- King's College London (GB)
- Université Paris Cité (FR)
- Charles University (CZ)
- Stavanger University Hospital (NO)
- Haukeland University Hospital (NO)
- Instituto de Salud Carlos III (ES)
- Hospital de Sant Pau (ES)
- Transylvania University of Brașov (RO)
- Universitat Internacional de Catalunya (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Assistance Publique – Hôpitaux de Paris (FR)
- University Hospital in Motol (CZ)
- Hôpital Fernand-Widal (FR)
- University of Stavanger (NO)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1002/acn3.52295
- Citations
- 2
- Primary Topic
- Lysosomal Storage Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Helse Vest
- Norges Forskningsråd
- Instituto de Salud Carlos III
- Departament de Salut, Generalitat de Catalunya