Formation of Substituted Benzocyclobutenes Starting from Donor–Acceptor Cyclopropanes
We describe an operationally simple, good-yielding, two-step cascade process to convert biscyclopropanes <b>1</b> into high-value benzocyclobutene building blocks <b>3</b>. This study highlights the novel reactivity of our "in-house" donor-acceptor cyclopropane, achieving complete diastereoselectivity and regioselectivity transfer.
Authors
- Laurent Comméiras (ORCID: https://orcid.org/0000-0003-4331-6198)
- Virginie Héran
- Yannick Carissan (ORCID: https://orcid.org/0000-0002-9876-0272)
- Bohdan Biletskyi (ORCID: https://orcid.org/0000-0003-3132-2566)
- Maxime Dousset
- P Colonna
- Gaëlle Chouraqui (ORCID: https://orcid.org/0000-0003-4719-137X)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Centrale Méditerranée (FR)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1021/acs.joc.4c02926
- Citations
- 2
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Aix-Marseille Université
- Agence Nationale de la Recherche
- Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche
- Centre National de la Recherche Scientifique