Identifying biomarkers and trajectories of executive functions and language development in the first 3 years of life: Design, methods, and findings of the Germina cohort study
This paper reports the methods and preliminary findings of Germina, an ongoing cohort study to identify biomarkers and trajectories of executive functions and language development in the first 3 years of life. 557 mother-infant dyads (mean age of mothers 33.7 years, 65.2% white, 48.7% male infants) have undergone baseline and are currently collecting data for other timepoints. A linear regression was used to predict baseline Bayley-III using scores derived from data-driven sparse partial least squares utilizing a multiple holdout framework of 15 domains. Significant associations were found between socioeconomic/demographic characteristics (<i>B</i> = 0.29), epigenetics (<i>B</i> = 0.11), EEG theta (<i>B</i> = 0.14) and beta activity (<i>B</i> = 0.11), and microbiome functional pathways (<i>B</i> = 0.08) domains, and infant development measured by the Bayley-III at T1, suggesting potential interventions to prevent impairments.
Authors
- Davi Pereira-Santos (ORCID: https://orcid.org/0000-0002-3766-3137)
- Patrícia Cristina Baleeiro Beltrão-Braga (ORCID: https://orcid.org/0000-0003-0004-1091)
- Fabiele Baldino Russo (ORCID: https://orcid.org/0000-0002-4076-1846)
- Marília O. Scliar (ORCID: https://orcid.org/0000-0001-9125-2171)
- Monike Teixeira (ORCID: https://orcid.org/0000-0002-3827-087X)
- Carla R. Taddei (ORCID: https://orcid.org/0000-0003-0869-0651)
- Paulo Alfonso Schüroff (ORCID: https://orcid.org/0000-0002-7808-7818)
- Adriana Argeu (ORCID: https://orcid.org/0000-0002-6061-7745)
- Maria Rita Passos‐Bueno (ORCID: https://orcid.org/0000-0002-9248-3008)
- Ana Cláudia Mattiello‐Sverzut (ORCID: https://orcid.org/0000-0002-4181-0718)
- Alícia Matijasevich (ORCID: https://orcid.org/0000-0003-0060-1589)
- Jaqueline Yu Ting Wang
- Verônica Euclydes (ORCID: https://orcid.org/0000-0003-0526-1456)
- Elizabeth A. Shephard (ORCID: https://orcid.org/0000-0003-4905-0562)
- Anthonieta Looman Mafra (ORCID: https://orcid.org/0000-0002-7612-8778)
- Alline C. Campos (ORCID: https://orcid.org/0000-0003-4258-3198)
- Danila Cristina Petian-Alonso (ORCID: https://orcid.org/0000-0002-2380-9174)
- Daniel Fatori (ORCID: https://orcid.org/0000-0001-7753-894X)
- Rogério Lerner (ORCID: https://orcid.org/0000-0002-8525-934X)
- André Fujita (ORCID: https://orcid.org/0000-0002-7756-7051)
- Gerson Shigeru Kobayashi
- Pedro Fonseca Zuccolo (ORCID: https://orcid.org/0000-0002-6340-6097)
- Guilherme V. Polanczyk (ORCID: https://orcid.org/0000-0003-2311-3289)
- Maria Teresa Bechere Fernandes (ORCID: https://orcid.org/0000-0002-9819-4573)
- Ana P. Carvalho (ORCID: https://orcid.org/0000-0001-5967-4200)
- Nathalia Ferrazzo Naspolini (ORCID: https://orcid.org/0000-0002-0768-3284)
- Helena Brentani (ORCID: https://orcid.org/0000-0001-5192-4682)
- Pedro Tótolo (ORCID: https://orcid.org/0000-0002-2468-3622)
- Caio Isaias
- Stephania Geraldini
- Gladys Guzmán
- Danilo Benette
Institutions
- Universidade de Ribeirão Preto (BR)
- Kyushu University (JP)
- Institut Pasteur (FR)
- Universidade de São Paulo (BR)
- Associação Paulista para o Desenvolvimento da Medicina (BR)
- Brazilian Society of Computational and Applied Mathematics (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Universidade Federal do ABC (BR)
Publication Details
- Journal
- Development and Psychopathology
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1017/s0954579425000069
- Citations
- 2
- Primary Topic
- Infant Development and Preterm Care
- Type
- article
- Field-Weighted Citation Impact
- 6.99