STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis
Th17-like Tfh cells play a pathogenic role in the EAU. STING deficiency promotes the differentiation and phenotypic transformation of Th17-like Tfh cells, exacerbating the inflammatory response in EAU. These findings highlight the potential of targeting STING to modulate Tfh cells as a therapeutic strategy for uveitis.
Authors
- Zuoyi Li
- Dan Liang (ORCID: https://orcid.org/0000-0002-7617-0204)
- Wenjie Zhu (ORCID: https://orcid.org/0000-0002-2255-240X)
- Wenru Su (ORCID: https://orcid.org/0000-0002-0506-6362)
- Minzhen Wang
- Xiuxing Liu (ORCID: https://orcid.org/0000-0001-5855-6624)
- Jun Huang
- Zhiqiang Xiao
- Yuxun Shi
- Yangyang Li (ORCID: https://orcid.org/0000-0002-5791-9443)
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-9797-8384)
- Zhuang Li (ORCID: https://orcid.org/0000-0002-6940-5693)
- Guanyu Chen (ORCID: https://orcid.org/0000-0002-0269-1357)
- Yanyan Xie (ORCID: https://orcid.org/0009-0004-6957-8131)
- Yunwei Hu
- Haixiang Huang
Institutions
- Nanchang University (CN)
- Sun Yat-sen University (CN)
- Second Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1167/iovs.66.3.8
- Citations
- 2
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 1.59