Circulating proteomic biomarkers for cerebral amyloid angiopathy screening and risk stratification
We identified plasma protein signatures in CAA using proteomics. A circulating hub protein panel was developed and validated, demonstrating high accuracy for disease screening. The hub protein panel effectively stratified CAA patients according to risk of future intracerebral hemorrhage. The circulating panel offers potential for CAA screening and risk stratification.
Authors
- Xin Cheng (ORCID: https://orcid.org/0000-0001-7816-0547)
- Han Tang (ORCID: https://orcid.org/0000-0002-0854-2766)
- Yunqing Ying (ORCID: https://orcid.org/0000-0001-9421-5683)
- M. Edip Gurol (ORCID: https://orcid.org/0000-0002-2169-4457)
- Jiajie Xu (ORCID: https://orcid.org/0000-0001-6819-4487)
- Yiwei Xia (ORCID: https://orcid.org/0000-0001-7360-732X)
- Ya Su (ORCID: https://orcid.org/0000-0002-2689-3148)
- Yuhui Sha (ORCID: https://orcid.org/0000-0002-2950-4830)
- Tingmeng Yan
- Jun Ni (ORCID: https://orcid.org/0000-0002-5939-8856)
- Feifan Xu (ORCID: https://orcid.org/0009-0003-3634-0015)
- Qiang Dong (ORCID: https://orcid.org/0000-0002-4387-2461)
- Jiayu Fu (ORCID: https://orcid.org/0000-0002-6838-582X)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Peking Union Medical College Hospital (CN)
- Massachusetts General Hospital (US)
- Huashan Hospital (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/alz.70044
- Citations
- 4
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 5.56
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China