Exon junction complexes regulate osteoclast‐induced bone resorption by influencing the NFATc1 m6A distribution through the “shield effect”
METTL14 controls osteoclast-mediated bone resorption by means of the methylation (4249 A) of the NFATc1 gene during osteoclast differentiation. Exon junction complexes (EJCs) protect the remaining methylation sites of the NFATc1 gene (located in the inner exon fragment of 50-200 nt) from hypermethylation and degradation. The "shield effect" disappears when the exon fragment is extended to 300 nt. Downstream, YTHDF2 induced the degradation of hypermethylation NFATc1 transcripts without site restriction.
Authors
- Sheng‐Nan Liu
- Zhe Wang (ORCID: https://orcid.org/0000-0002-9735-2007)
- Jingang Yang (ORCID: https://orcid.org/0009-0006-0767-0244)
- Xing Li (ORCID: https://orcid.org/0000-0003-3149-9783)
- Wei Wang (ORCID: https://orcid.org/0009-0006-6757-7674)
- Jiang Li (ORCID: https://orcid.org/0000-0003-2372-6624)
- Zheng Wang (ORCID: https://orcid.org/0000-0003-1075-2778)
- Ping Zhang (ORCID: https://orcid.org/0000-0001-6374-673X)
- Wei Feng (ORCID: https://orcid.org/0000-0001-7913-2011)
- Yaqin Zhu (ORCID: https://orcid.org/0000-0001-7068-934X)
- Bao Sun
Institutions
- Shanxi Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
- Tongren Hospital (CN)
- First Hospital of Shanxi Medical University (CN)
- National Clinical Research (US)
- Jinan Stomatological Hospital (CN)
- Concordia University (CA)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/ctm2.70266
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province