Effects of Therapeutic Antibiotic Exposure on the Oropharyngeal and Fecal Microbiota in Infants With Cystic Fibrosis
β-lactam antibiotic exposure was followed by marked alterations in both OP and fecal microbiota. While microbiota appeared to rebound after treatment in both sample types, our results suggest that fecal microbiota recovered less than OP. The clinical consequences of these findings should be studied in IWCF and other populations frequently treated with antibiotics.
Authors
- Don B. Sanders (ORCID: https://orcid.org/0000-0001-6265-6249)
- Hillary S. Hayden (ORCID: https://orcid.org/0000-0001-7372-9853)
- Adrian J. Verster (ORCID: https://orcid.org/0009-0003-5039-0780)
- Lucas R. Hoffman (ORCID: https://orcid.org/0000-0001-8864-6751)
- Christopher Siracusa (ORCID: https://orcid.org/0000-0001-8681-1725)
- Stephen J. Salipante (ORCID: https://orcid.org/0000-0001-8355-6992)
- Adam Waalkes (ORCID: https://orcid.org/0000-0002-5202-1108)
- Sydney E. Ross (ORCID: https://orcid.org/0009-0002-7800-9278)
- Alex Eng
- Benjamin T. Kopp (ORCID: https://orcid.org/0000-0002-2021-7990)
- Maria T. Nelson (ORCID: https://orcid.org/0000-0002-8775-8628)
- Michael J. Rock (ORCID: https://orcid.org/0000-0001-9665-1737)
- Drake C. Bouzek (ORCID: https://orcid.org/0000-0002-8418-3072)
- Kelsi Penewit (ORCID: https://orcid.org/0000-0003-1454-6381)
Institutions
- University of Wisconsin–Madison (US)
- Emory University (US)
- University of Washington (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of Cincinnati (US)
Publication Details
- Journal
- Pediatric Pulmonology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/ppul.71024
- Citations
- 1
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- University of Washington
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of Diabetes and Digestive and Kidney Diseases