Phomaligol J, a New Cyclohexenone With Antibacterial Activity From a Pufferfish‐Associated Fungus <i>Aspergillus austwickii</i>
A new cyclohexenone, phomaligol J (1), along with nine known compounds (2-10) were isolated from the liquid culture of the pufferfish-associated Aspergillus austwickii collected from Yangma Island, Yantai. Their structures were determined by extensive spectroscopic data analysis, high resolution electrospray ionization mass spectrometry (HRESIMS), electronic circular dichroism (ECD), and the comparison with reported data in the literature. In bioactivity, all isolated compounds were evaluated for antibacterial activity against 12 bacterial strains. Notably, compound 1 exhibited moderate antibacterial activity against Staphylococcus aureus with a minimum inhibitory concentration (MIC) value of 40 µg/mL.
Authors
- Jin Yang (ORCID: https://orcid.org/0009-0001-6263-0695)
- Rui Sun (ORCID: https://orcid.org/0000-0001-6353-2643)
- Haifeng Wang (ORCID: https://orcid.org/0000-0002-0672-7468)
- Chao Ma (ORCID: https://orcid.org/0000-0003-1444-4668)
- Huifang Wang (ORCID: https://orcid.org/0000-0001-6690-2179)
- Xuwen Li (ORCID: https://orcid.org/0000-0002-3510-5908)
- Wenjie Du (ORCID: https://orcid.org/0000-0001-5698-4617)
Institutions
- Shenyang Pharmaceutical University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Materia Medica (CN)
- Advanced Research Institute (US)
- Drug Discovery Laboratory (Norway) (NO)
- State Key Laboratory of Drug Research
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1002/cbdv.202500503
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00