Ruxolitinib Delays Nucleus Pulposus Cell Senescence in Rat Intervertebral Discs
NPC senescence is characterized by low cell proliferation, a high apoptosis ratio, cell cycle arrest, and generation of senescence-associated secretory phenotypes. NPC senescence can be delayed by inhibiting JAK2/STAT3 signaling using ruxolitinib.
Authors
- Yakefu Abulizi
- Huiling Hao (ORCID: https://orcid.org/0009-0001-6654-5922)
- Xiaoyu Cai (ORCID: https://orcid.org/0000-0002-1547-0764)
- Weibin Sheng (ORCID: https://orcid.org/0000-0002-6644-3221)
- Rui Cao (ORCID: https://orcid.org/0000-0002-0816-8030)
- Shutao Gao (ORCID: https://orcid.org/0000-0002-8441-6606)
- Tao Xu (ORCID: https://orcid.org/0000-0002-7683-7785)
- Weidong Liang (ORCID: https://orcid.org/0000-0002-8290-3216)
- Shuwen Zhang (ORCID: https://orcid.org/0000-0002-5969-1737)
- Chuanhui Xun
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/jsp2.70044
- Citations
- 3
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- National Natural Science Foundation of China