Improved Detection of Extrapulmonary and Paucibacillary Pulmonary Tuberculosis by Xpert MTB Host Response in a Tuberculosis Low-Endemic, High-Resource Setting
Capillary Xpert MTB-HR improves detection of sputum PCR-negative, culture-verified PTB and is promising as a rule-out test in EPTB. MTB-HR score and bacterial burden were highly correlated. We suggest a graded MTB-HR score as more clinically relevant than a binary result.
Authors
- Thomas Schön (ORCID: https://orcid.org/0000-0003-4849-1286)
- Christopher Sundling (ORCID: https://orcid.org/0000-0002-6138-690X)
- Judith Bruchfeld (ORCID: https://orcid.org/0000-0001-5399-0982)
- Gabrielle Fröberg (ORCID: https://orcid.org/0000-0002-0551-0072)
- Erik Södersten (ORCID: https://orcid.org/0000-0002-2998-4889)
- Elin Folkesson (ORCID: https://orcid.org/0000-0002-6585-6235)
Institutions
- Linköping University (SE)
- Karolinska University Hospital (SE)
- Solvay (Belgium) (BE)
- Karolinska Institutet (SE)
- Landstinget i Kalmar län (SE)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1093/infdis/jiaf110
- Citations
- 5
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 6.98
Funders
- Karolinska Institutet