Altered triple network model connectivity is associated with cognitive function and depressive symptoms in older adults
Resting-state neuroimaging markers are associated with symptoms of cognitive decline and late-life depression. Symptom-associated connectivity alterations were present across three major brain networks of interest, including the salience, default mode, and executive control networks. Some regions of interest are associated with both cognitive function and depressive symptoms, including the left amygdala, left hippocampus, and bilateral ventral tegmental area.
Authors
- Hyun Woong Roh (ORCID: https://orcid.org/0000-0002-1333-358X)
- Helmet T. Karim (ORCID: https://orcid.org/0000-0002-9286-0694)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Chang Hyung Hong (ORCID: https://orcid.org/0000-0003-3258-7611)
- Sang Joon Son (ORCID: https://orcid.org/0000-0001-7434-7996)
- Antonija Kolobaric (ORCID: https://orcid.org/0000-0001-7326-585X)
- Pâmela C.L. Ferreira (ORCID: https://orcid.org/0000-0003-2134-9829)
- You Jin Nam (ORCID: https://orcid.org/0000-0002-6603-5586)
- Andrew Gerlach (ORCID: https://orcid.org/0000-0002-4022-1356)
- Howard Jay Aizenstein (ORCID: https://orcid.org/0000-0003-4897-6582)
- Bruna Bellaver (ORCID: https://orcid.org/0000-0002-2212-3373)
- Yong Hyuk Cho (ORCID: https://orcid.org/0000-0002-2570-7278)
- Eldin Jašarević (ORCID: https://orcid.org/0000-0001-8174-0710)
- Bumhee Park (ORCID: https://orcid.org/0000-0002-5271-1571)
- Carmen Andreescu (ORCID: https://orcid.org/0000-0003-3767-5127)
- Jin Wook Choi (ORCID: https://orcid.org/0000-0002-2396-4705)
- Sunhwa Hong
- Narae Kim (ORCID: https://orcid.org/0000-0001-7354-5974)
- Dongyun Lee (ORCID: https://orcid.org/0000-0002-3977-3663)
Institutions
- University of Pittsburgh (US)
- Magee-Womens Research Institute (US)
- Ajou University (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/alz.14493
- Citations
- 4
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.72
Funders
- Korea Dementia Research Center
- Food Industry Research and Development Institute
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea