Trophoblast‐specific Deptor knockdown enhances trophoblast nutrient transport and fetal growth in mice
This is the first report showing that trophoblast-specific Deptor<sup>KD</sup> is sufficient to activate mTOR signaling, a master regulator of placental function, which increases the TPM System A and L amino acid transporter expression and activity. We also propose that Deptor expression is mechanistically linked to placental mTOR signaling and fetal growth. Furthermore, modulation of DEPTOR signaling may represent a promising approach to improve outcomes in pregnancies characterized by abnormal fetal growth.
Authors
- Men‐Jean Lee (ORCID: https://orcid.org/0000-0003-3288-1909)
- Adam J. Chicco (ORCID: https://orcid.org/0000-0003-0131-6851)
- Shaikh M. Atif (ORCID: https://orcid.org/0000-0002-7928-5365)
- Johann Urschitz
- Rodrigo Barbano Weingrill (ORCID: https://orcid.org/0000-0003-3699-4388)
- Ramón A. Lorca (ORCID: https://orcid.org/0000-0001-9159-1739)
- Sam Blessen J. Fredrick
- Lance G. A. Nunes
- Fredrick J. Rosario (ORCID: https://orcid.org/0000-0001-7282-7005)
Institutions
- University of Hawaiʻi at Mānoa (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
- Colorado State University (US)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1111/apha.70012
- Citations
- 3
- Primary Topic
- Genetic Syndromes and Imprinting
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development