Comparison of methylprednisolone alone versus intravenous immunoglobulin plus methylprednisolone for multisystem inflammatory syndrome in children (MIS-C)
Initial treatment with methylprednisolone monotherapy appears not inferior in effectiveness to adjunctive IVIG plus methylprednisolone in MIS-C. Further investigations in randomised controlled trials deserve to be undergone to clarify if IVIG-sparing glucocorticoids are a viable option for achieving favourable outcomes in MIS-C, particularly in resource-limited settings with barriers approaching IVIG therapy.
Authors
- Chi Quynh Le
- Canh Ngoc Hoang (ORCID: https://orcid.org/0000-0003-2674-3024)
- Phan Hữu Phúc (ORCID: https://orcid.org/0000-0002-0381-446X)
- Ha Nguyen Thi Thu (ORCID: https://orcid.org/0000-0002-9822-3688)
- Tung Viet Cao (ORCID: https://orcid.org/0000-0002-7991-5638)
- Dien Minh Tran
Institutions
- Vietnam National University, Hanoi (VN)
- Vietnam National Children's Hospital (VN)
- Children's Hospital 1 (VN)
Publication Details
- Journal
- BMJ Paediatrics Open
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1136/bmjpo-2024-003148
- Citations
- 3
- Primary Topic
- Kawasaki Disease and Coronary Complications
- Type
- article
- Field-Weighted Citation Impact
- 6.02