Regulation of <scp>BzATP</scp>‐Induced Blood–Brain Barrier Endothelial Cell Hyperpermeability by <scp>NLRP3</scp> Inflammasome Inhibition
NLRP3 inflammasome signaling is critical to BBB endothelial cell dysfunction. Extracellular ATP is an upstream promoter of BBB hyperpermeability. NLRP3 inflammasome activation leads to subsequent caspase-1 and MMP-9-mediated tight junction protein disarray.
Authors
- Amrendra K. Singh (ORCID: https://orcid.org/0000-0001-7263-7914)
- O’lisa Yaa Waithe
- Binu Tharakan
- Gabriela Seplovich (ORCID: https://orcid.org/0000-0001-8697-142X)
- Aliyah Anderson (ORCID: https://orcid.org/0000-0002-9115-5379)
- Chris Greene (ORCID: https://orcid.org/0000-0003-4192-9433)
- Saravanakumar Muthusamy (ORCID: https://orcid.org/0000-0002-3872-8158)
- Oluwatoyin Olagunju (ORCID: https://orcid.org/0000-0002-9472-4004)
Institutions
- Morehouse School of Medicine (US)
Publication Details
- Journal
- Microcirculation
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1111/micc.70006
- Citations
- 3
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.53
Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke