Preclinical Alzheimer's disease shows alterations in circulating neuronal‐derived extracellular vesicle microRNAs in a multiethnic cohort
Neuronal-derived extracellular vesicles (NDEVs) carry potential brain biomarkers. We tested the association between NDEV microRNAs (miRNAs) and Alzheimer's disease (AD). Fourteen NDEV miRNAs were associated with AD. Preclinical AD displayed more pronounced transcriptional changes than clinical AD. miRNA-target genes were enriched in pathways associated with neurodegeneration.
Authors
- Adam M. Brickman (ORCID: https://orcid.org/0000-0002-5125-8226)
- Kasey Brennan
- Vrinda Kalia (ORCID: https://orcid.org/0000-0003-2244-6663)
- Gary W. Miller (ORCID: https://orcid.org/0000-0001-8984-1284)
- Andrea Baccarelli (ORCID: https://orcid.org/0000-0002-3436-0640)
- Haotian Wu (ORCID: https://orcid.org/0000-0002-6271-0249)
- Paolo Reho (ORCID: https://orcid.org/0000-0002-1423-8680)
- Badri Narayan Vardarajan (ORCID: https://orcid.org/0000-0002-5560-4085)
- Fang Wang (ORCID: https://orcid.org/0000-0002-9192-6858)
- Richard Mayeux
- Gabriela L. Jackson
- Erez Eiten
Institutions
- NewYork–Presbyterian Hospital (US)
- Harvard University (US)
- NeuroBioTex (United States) (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/alz.70050
- Citations
- 10
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 8.06