Mast cells and corticotropin‐releasing hormone receptors in duodenal tissue of children with functional dyspepsia
Our data show increased MC density and stronger CRHR2 staining in patients with FD and in patients with a psychiatric history. Our data support a pathophysiologic theory of FD development via a "gut-brain axis" intersecting at the level of MCs with influence via peripheral CRH.
Authors
- Zarela Molle‐Rios (ORCID: https://orcid.org/0000-0001-6495-0812)
- Haley Pearlstein
- Timothy Chao (ORCID: https://orcid.org/0000-0003-0082-5013)
- Zhaoping He (ORCID: https://orcid.org/0000-0002-4722-1674)
Institutions
- Thomas Jefferson University (US)
- Nemours Children's Health System (US)
Publication Details
- Journal
- Journal of Pediatric Gastroenterology and Nutrition
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1002/jpn3.12477
- Citations
- 1
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.81