Synthesis of <i>meta</i>-Sulfonylpyridines via Copper(II)-Catalyzed Cascade Sulfonylation/Cyclization/Aromatization of Tertiary Enamides with Sulfonylhydrazides
A copper(II)-catalyzed radical cascade reaction of <i>N</i>-propargyl enamides with sulfonyl hydrazides was developed, which provided an unprecedented method for the direct synthesis of <i>meta</i>-sulfonylpyridines in high efficiency with good functional group compatibility and simple operation. Mechanistic studies indicated that this tandem process might be composed of the radical addition, intramolecular cyclization and oxidative aromatization.
Authors
- Jinchun Chen
- Xin‐Ming Xu (ORCID: https://orcid.org/0000-0002-3015-9050)
- Yuhang Yao (ORCID: https://orcid.org/0000-0002-3477-7075)
- Qian Liu (ORCID: https://orcid.org/0000-0003-1692-3267)
- Zhongyuan Zhao (ORCID: https://orcid.org/0000-0002-8787-8267)
- Jiping Wang (ORCID: https://orcid.org/0000-0003-2241-8734)
- Xiaoxu Chen (ORCID: https://orcid.org/0000-0003-0872-1139)
- Lu Shao
Institutions
- Yantai University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1021/acs.joc.5c00140
- Citations
- 1
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Yantai University
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province