First trimester circulating miR-208b-3p and miR-26a-1-3p are relevant to the prediction of gestational hypertension
The combination of circulating miR-208b-3p and miR-26a-1-3p with first trimester MAP offers good performance as early predictors of GH. Interestingly, these miRNAs target pathways related to the cardiovascular system and could thus be relevant to the pathophysiology of GH. These miRNAs thus provide a novel avenue to identify women at risk and could lead to even more adequate obstetrical care to reduce the risk of complications associated with GH.
Authors
- Pierre‐Étienne Jacques (ORCID: https://orcid.org/0000-0002-3961-294X)
- Cécilia Légaré (ORCID: https://orcid.org/0000-0003-4770-6230)
- Véronique Desgagné
- Andrée‐Anne Clément (ORCID: https://orcid.org/0000-0001-9173-471X)
- Kathrine Thibeault
- Marie‐France Hivert (ORCID: https://orcid.org/0000-0001-7752-2585)
- Frédérique White (ORCID: https://orcid.org/0000-0002-3442-0033)
- William D. Fraser (ORCID: https://orcid.org/0000-0001-9042-2415)
- Anne‐Marie Côté (ORCID: https://orcid.org/0000-0002-1252-769X)
- Patrice Perron (ORCID: https://orcid.org/0000-0003-4413-6199)
- Luigi Bouchard (ORCID: https://orcid.org/0000-0002-7852-0722)
- Michelle S. Scott (ORCID: https://orcid.org/0000-0001-6231-7714)
- Renée Guérin
Institutions
- Université de Sherbrooke (CA)
- Harvard University (US)
- Centre Hospitalier Universitaire de Sherbrooke (CA)
- University at Albany, State University of New York (US)
- Massachusetts General Hospital (US)
- Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean (CA)
- Harvard Pilgrim Health Care (US)
- Université Laval (CA)
Publication Details
- Journal
- BMC Pregnancy and Childbirth
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1186/s12884-025-07349-x
- Citations
- 3
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 6.17
Funders
- Diabète Québec
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé