COMPARISON OF PREGABALIN 75MG AND 150 MG FOR ATTENUATION OF HEMODYNAMIC STRESS RESPONSE ASSOCIATED WITH ENDOTRACHEAL INTUBATION AMONG PATIENTS UNDERGOING GENERAL ANESTHESIA FOR ELECTIVE SURGERIES

Background: Hemodynamic and cardiovascular responses are linked to respiratory tract manipulation during tracheal intubation and laryngoscopy. The insertion of a flexible plastic tube during general anesthesia is known as tracheal intubation. The hemodynamic response linked to endotracheal intubation is lessened by pregabalin taken alone. The attenuation of hemodynamic responses is verified by comparing different dosages. Objective: The objective of this research is to compares the heart rate and arterial pressure increases in 150 mg and 75 mg pregabalin individuals. These dosages will be tested to see whether they reduce endotracheal intubation-related hemodynamic stress in elective general anesthesia patients. Study design: Randomized controlled trial Study place and study period: Department of Anesthesiology, Sir Ganga Ram Hospital Lahore for six months from 1-6-24 to 31-12-2024. Methodology: Total 150 cases were enrolled in this study. Randomization was done through lottery method. 75 patients in group A received oral Pregabalin 75mg and 75 patients in group B received oral Pregabalin 150mg 1-h prior to induction of anesthesia. Endotracheal intubation was performed on all patients. The heart rate and mean arterial pressure (MAP) were measured at the beginning and 5 minutes following intubation. The data was analysed in SPSS version 25. Results: The mean age of the patients was note as 31.02±6.49 years. In this study, 69.33% patients were males whereas 30.67% patients were females.  The mean value of heart rate at baseline was noted as 82.22±6.92bpm. The mean value of MAP at baseline was noted as 91.67±2.26 mmHg. The mean HR value at baseline of group A patients was noted as 81.50±6.59 bpm which was increased to 97.28±5.52 bpm after 5 minutes, thus the mean HR increase was 15.77±4.99 bpm. In group B, mean HR was 82.94±7.19 bpm which was increased to 94.69±6.09 bpm after 5 minutes, thus the mean HR increase was 11.74±5.23 bpm. There was significant difference between the HR in both groups i.e. p-value<0.05. The mean MAP at baseline of group A patients was 92.18±2.34 mmHg which was increased to 99.32±2.58mmHg and mean MAP increase was calculated as 7.13±2.35mmHg. In group B, mean MAP at baseline was 91.16±2.06mmHg which was increased to 96.61±2.77mmHg and the mean MAP increase in group B was 5.45±2.10 mmHg. There is significant difference between MAP increase in both groups i.e. p-value<0.05. Conclusion: The findings of our research indicate that Pregabalin 150mg has a superior effect in terms of reduced variability in heart rate and mean arterial pressure when compared to Pregabalin 75mg.