Piezo1 promotes intervertebral disc degeneration through the Ca2+/F-actin/Yap signaling axis
Overall, the results of the present study indicate that increased expression of Piezo1 is closely related to the occurrence and development of IVDD and that the Piezo1-mediated Ca<sup>2+</sup>/F-actin/Yap axis contributes to this process. Thus, targeting Piezo1 may provide a new strategy for the treatment of IVDD.
Authors
- Xingzhi Jing (ORCID: https://orcid.org/0000-0001-6916-4204)
- Mingtong Sun (ORCID: https://orcid.org/0000-0002-5184-5228)
- Tong Cao (ORCID: https://orcid.org/0000-0002-4858-0804)
- Fushuai Peng
- Tao Li (ORCID: https://orcid.org/0000-0002-9165-3239)
- Fei Chen (ORCID: https://orcid.org/0000-0002-5972-0745)
- Zhenzhen Li (ORCID: https://orcid.org/0000-0002-7035-6657)
Institutions
- Qingdao University (CN)
- Shandong Provincial Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Yidu Central Hospital of Weifang (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1186/s10020-025-01147-z
- Citations
- 16
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 18.42